Patient-Specific and Gene-Corrected Induced Pluripotent Stem Cell-Derived Endothelial Cells Elucidate Single-Cell Phenotype of Pulmonary Veno-Occlusive Disease

Three pulmonary veno-occlusive disease patients who carried the compound heterozygous variants of EIF2AK4 and two healthy controls were recruited and induced pluripotent stem cells were generated from human peripheral blood mononuclear cells.