Aging Drives Tet2+/- Clonal Hematopoiesis via IL-1 Signaling

Using bone marrow (BM) transplantation and newly developed genetic mosaicism mouse models of Tet2+/--driven clonal hematopoiesis of indeterminate potential, scientists observed an association between increased Tet2+/- clonal expansion and higher BM levels of the inflammatory cytokine IL-1 upon aging.

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