Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma

Human H-ferritin (HFn), regorafenib (REGO), and Cu2+ were rationally designed as a brain-targeted nanoplatform, fulfilling the task of site-specific delivery and manipulating autophagy and cuproptosis against glioblastoma multiforme.