Generation of Neural Organoids for Spinal-Cord Regeneration via the Direct Reprogramming of Human Astrocytes

The authors showed that human astrocytes could be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, the suppression of p53 and the provision of the small molecules CHIR99021, SB431542, RepSox and Y27632.
[Nature Biomedical Engineering]
Abstract
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