CCL18 Signaling from Tumor-Associated Macrophages Activates Fibroblasts to Adopt a Chemoresistance-Inducing Phenotype

CCL18 secreted by tumor-associated macrophages activated a CD10+GPR77+ cancer-associated fibroblast (CAF) phenotype in normal breast-resident fibroblasts, enriching cancer stem cells and inducing chemoresistance in breast cancer cells.