CCL18 Signaling from Tumor-Associated Macrophages Activates Fibroblasts to Adopt a Chemoresistance-Inducing Phenotype
CCL18 secreted by tumor-associated macrophages activated a CD10+GPR77+ cancer-associated fibroblast (CAF) phenotype in normal breast-resident fibroblasts, enriching cancer stem cells and inducing chemoresistance in breast cancer cells.
[Molecular Therapy] Researchers review the latest advancements in improving the delivery of different therapeutic agents to the central nervous system and comment upon outstanding questions in the field of neurological lysosomal storage diseases.
[Nature Genetics] Investigators performed an integrated analysis of 116 tumors, including single-cell transcriptome and chromatin accessibility, 3D chromatin architecture, and epigenomic profiles, and showed that K27M-mutant gliomas faithfully maintain chromatin configuration at developmental genes consistent with anatomically distinct oligodendrocyte precursor cells.
[Nature Communications] Researchers showed that the RNA-binding protein, Musashi-1 is an essential mediator of G3 medulloblastoma in both MYC-overexpressing mouse models and patient-derived xenografts.