CCL18 Signaling from Tumor-Associated Macrophages Activates Fibroblasts to Adopt a Chemoresistance-Inducing Phenotype
CCL18 secreted by tumor-associated macrophages activated a CD10+GPR77+ cancer-associated fibroblast (CAF) phenotype in normal breast-resident fibroblasts, enriching cancer stem cells and inducing chemoresistance in breast cancer cells.
[Haematologica] 301 patients with a median age 60 years were enrolled. Of them, 287 and 274 patients collected ≥2 and ≥4×106 CD34+ cells/kg, respectively, with a median of 9.9×106 CD34+ cells/kg collected.
[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.