Induction of Cross-Neutralizing Antibodies by a Permuted Hepatitis C Virus Glycoprotein Nanoparticle Vaccine Candidate

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Most recombinant Hepatitis C virus glycoprotein vaccines, which usually include only E2, induce only weak neutralizing antibody responses. Therefore, investigators described recombinant soluble E1E2 immunogens that were generated by permutation of the E1 and E2 subunits.
[Nature Communications]
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