STAT3 Gain-of-Function Mutations Connect Leukemia With Autoimmune Disease by Pathological NKG2Dhi CD8+ T Cell Dysregulation and Accumulation

The authors analyzed patients and mice with germline STAT3 gain-of-function (GOF) mutations, and found that these mutations drove the accumulation of effector CD8+ T cell clones highly expressing NKG2D, the receptor for stress-induced MHC-class-I-related molecules.