An NKX-COUP-TFII Morphogenetic Code Directs Mucosal Endothelial Addressin Expression

The authors identified conserved NKX-COUP-TFII composite elements in regulatory regions of Madcam1 and St6gal1 that bind intestinal homeodomain protein NKX2-3 cooperatively with venous nuclear receptor COUP-TFII to activate transcription.