Endothelial Cell-Specific Mineralocorticoid Receptor Activation Promotes Diastolic Dysfunction in Diet-Induced Obese Male Mice

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To determine the specific role of mineralocorticoid receptor in endothelial cells (ECMR) activation in the pathogenesis of diastolic dysfunction, scientists fed four-week-old ECMR knockout male mice and littermates with either a Western diet or chow diet for 16 weeks.
[American Journal of Physiology-Regulatory, Integrative and Comparative Physiology]
Abstract