SSTR2 as an Anatomical Imaging Marker and a Safety Switch to Monitor and Manage CAR T Cell Toxicity

Using intercellular adhesion molecule 1-specific CAR T cells that secrete interleukin-12 as a model, herein scientists examined the potential of somatostatin receptor 2 (SSTR2) as a safety switch when combined with the SSTR2-specific maytansine-octreotate conjugate PEN-221.