Tim-4 Reprograms Cholesterol Metabolism to Suppress Antiviral Innate Immunity by Disturbing the Insig1-SCAP Interaction in Macrophages

Mechanistically, T cell immunoglobulin and mucin domain-containing molecule 4 (Tim-4) disturbed the Insig1-SCAP interaction and promoted SCAP-SREBP2 complex translocation to the Golgi apparatus.