The ENL YEATS Epigenetic Reader Domain Critically Links MLL-ENL to Leukemic Stem Cell Frequency in t(11; 19) Leukemia

0
293
Scientists found the YEATS domain was retained in 84.1% of MLL-ENL patients and crucial for MLL-ENL-mediated leukemogenesis in mouse models. Mechanistically, deletion of the YEATS domain impaired MLL-ENL fusion protein binding and decreased expression of pro-leukemic genes like Eya1 and Meis1.
[Leukemia]
Abstract