Modular UBE2H-Ctlh E2-E3 Complexes Regulate Erythroid Maturation

By measuring the proteomic landscape of in vitro human erythropoiesis models, investigators found dynamic differential expression of subunits of the CTLH E3 ubiquitin ligase complex that formed maturation stage-dependent assemblies of topologically homologous RANBP9- and RANBP10-CTLH complexes.