The Insulin and IGF Signaling Pathway Sustains Breast Cancer Stem Cells by IRS2/PI3K-Mediated Regulation of MYC

Researchers reported that insulin/insulin-like growth factor (IGF) signaling supported breast CSC self-renewal in an IRS2-phosphatidylinositol 3-kinase (PI3K)-dependent manner that involved the activation and stabilization of MYC.