Micromechanical Property Mismatch between Pericellular and Extracellular Matrices Regulates Stem Cell Articular and Hypertrophic Chondrogenesis

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Researchers reported a unique biomaterial-based engineering strategy to create cartilage-tissue equivalents possessing pericellular matrix (PCM)-ECM microarchitecture of native cartilage, where human mesenchymal stem cell-laden soft microgels representing PCM were encapsulated in stiff hydrogels representing ECM.
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