Inactivation of LATS1/2 Drives Luminal-Basal Plasticity to Initiate Basal-Like Mammary Carcinomas

Using genetic mouse models and ex vivo primary organoid cultures, scientists showed that conditional co-deletion of the LATS1 and LATS2 kinases in mature mammary luminal epithelial cells promoted the development of Krt14 and Sox9-expressing basal-like carcinomas that metastasize over time.