Increased CHCHD2 Expression Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis via Notch/Osteopontin Signaling

Coiled-coil-helix-coiled-coil-helix domain-containing (CHCHD2)-overexpressing hepatocytes activated hepatic stellate cells by upregulating osteopontin levels, a downstream mediator of Notch signals.