Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro

CTHRC1 expression at both RNA and protein levels was significantly upregulated in the lung tissues of asthmatic mice. A cell model with transforming growth factor-β induction in bronchial epithelial cells was conducted to verify the effects of CTHRC1 on epithelial-mesenchymal transition, a classic mechanism that mediates airway remodeling.