α1 Adrenoreceptor Antagonism Mitigates Extracellular Mitochondrial DNA Accumulation in Lung Fibrosis Models and in Patients with IPF

Researchers reported that noradrenaline derived from the lung’s adrenergic nerve supply drives αSMA-expressing fibroblast accumulation via mechanisms involving α1 adrenoreceptors and mitochondrial DNA.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology]
Abstract
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