Ablation of Adar1 in Myeloid Cells Imprints a Global Antiviral State in the Lung and Heightens Early Immunity against SARS-CoV-2

Investigators showed that ADAR1 deletion in CD11c+ antigen presenting cells lead to a skewed myeloid cell compartment enriched in inflammatory cDC2-like cells, enhanced numbers of activated tissue resident memory T cells in the lung, the imprinting of a broad antiviral transcriptional signature across both immune and non-immune cells.