A 3D Multifunctional Bi-layer Scaffold to Regulate Stem Cell Behaviors and Promote Osteochondral Regeneration

Researchers developed a 3D multifunctional bi-layer scaffold composed of a kartogenin (KGN)-loaded GelMA hydrogel as an upper layer mimicking a cartilage-specific ECM and a hydroxyapatite-coated 3D printed polycaprolactone porous scaffold as a lower layer simulating subchondral bone.