Folic Acid-Modified Lactoferrin Nanoparticles Coated with a Laminarin Layer Loaded Curcumin with Dual-Targeting for Ulcerative Colitis Treatment

Given the targeting action of lactoferrin (LF) by binding to the LF receptors of intestinal epithelial cells and of folic acid (FA) by binding to the FA receptors of macrophages, investigators developed an oral dual-targeting nanosystem.