Hepatocyte Growth Factor-Mediated Apoptosis Mechanisms of Cytotoxic CD8+ T Cells in Normal and Cirrhotic Livers

Using a diethylnitrosamine-induced liver fibrosis/cirrhosis mouse model, immunostaining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, scientists found that hepatocyte growth factor secretion was significantly higher at 10 weeks post-diethylnitrosamine, the liver cirrhotic phase, than at three weeks post-DEN, the liver fibrotic phase