Precision Targeting of Autoantigen-Specific B Cells in Muscle-Specific Tyrosine Kinase Myasthenia Gravis with Chimeric Autoantibody Receptor T Cells

Researchers engineered T cells to express a muscle-specific tyrosine kinase (MuSK) chimeric autoantibody receptor with CD137-CD3ζ signaling domains for precision targeting of B cells expressing anti-MuSK autoantibodies.