Precision Targeting of Autoantigen-Specific B Cells in Muscle-Specific Tyrosine Kinase Myasthenia Gravis with Chimeric Autoantibody Receptor T Cells
Researchers engineered T cells to express a muscle-specific tyrosine kinase (MuSK) chimeric autoantibody receptor with CD137-CD3ζ signaling domains for precision targeting of B cells expressing anti-MuSK autoantibodies.
[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
[Cell Death Discovery] Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.