Improvements in Gut Microbiota Dysbiosis in Aged Mice Transplanted with Adipose-Derived Stem Cells
The authors used C57BL/6J mice of different ages to carry out the and extracted adipose-derived stem cells from young mice as donors. They further analyzed the species composition of intestinal microorganisms.
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.