Fucosylation of HLA-DRB1 Regulates CD4⁺ T Cell-mediated Anti-Melanoma Immunity and Enhances Immunotherapy Efficacy

The authors reported that dietary administration of L-fucose induced fucosylation and cell surface enrichment of the major histocompatibility complex-II protein HLA-DRB1 in melanoma cells, triggering CD4+ T cell-mediated increases inintratumoral immune cells and anti-tumor immunity.