DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

Using Keratin 14–Cre–driven ablation of Tet genes in skin epithelial cells, investigators demonstrated that ablation of Tet2/Tet3 resulted in marked alterations of hair shape and length followed by hair loss.