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e.g. organoids

Human Early-Onset Dementia Caused by DAP12 Deficiency Reveals a Unique Signature of Dysregulated Microglia

Single-nucleus RNA-sequencing analysis of brain specimens from DAP12-deficient Nasu-Hakola disease individuals revealed a unique microglia signature indicating heightened RUNX1, STAT3 and transforming growth factor-β signaling pathways that mediate repair responses to injuries.
[Nature Immunology]
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