Ubiquitin Receptor PSMD4/Rpn10 Is a Novel Therapeutic Target in Multiple Myeloma
Since proteasome inhibition is a common therapeutic strategy in multiple myeloma (MM), scientists investigated Rpn10, a subunit of the 19S proteasome unit, and found that it is highly expressed in MM cells versus normal plasma cells.
[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
[Life Science Alliance] Scientists found a higher HCC incidence in methamphetamine (METH) abusers. METH promoted cellular proliferation, migration, and invasion in two human-derived HCC cells.
[Cell Death Discovery] Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.