Targeted Zinc-Finger Repressors to the Oncogenic HBZ Gene Inhibit Adult T-cell Leukemia (ATL) Proliferation

A series of zinc-finger protein repressors were designed to target within the human T-lymphotropic virus type I (HTLV-I) promoter that drove HTLV-I bZIP factor (HBZ) expression at highly conserved sites covering a wide range of HTLV-I genotypes.