NewslettersCancer Stem Cell NewsMesenchymal Cell NewsLoss of RanGAP1 Drives Chromosome Instability and Rapid Tumorigenesis of OsteosarcomaBy Bob - January 25, 20230300Researchers showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which was associated with a high rate of chromothripsis.[Developmental Cell]AbstractGraphical Abstract