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e.g. organoids

Loss of RanGAP1 Drives Chromosome Instability and Rapid Tumorigenesis of Osteosarcoma

Researchers showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which was associated with a high rate of chromothripsis.
[Developmental Cell]
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