Loss of RanGAP1 Drives Chromosome Instability and Rapid Tumorigenesis of Osteosarcoma

Researchers showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which was associated with a high rate of chromothripsis.
[Developmental Cell]
AbstractGraphical Abstract
spot_img

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News