Targeting De Novo Lipid Synthesis Induces Lipotoxicity and Impairs DNA Damage Repair in Glioblastoma Mouse Models

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Investigators reported that YTX-7739 triggered lipotoxicity in patient-derived glioblastoma stem-like cells (GSCs) and inhibits fatty acid desaturation in GSCs orthotopically implanted in mice.
[Science Translational Medicine]
AbstractPress Release