Epithelial Disruption Drives Mesendoderm Differentiation in Human Pluripotent Stem Cells by Enabling TGF-β Protein Sensing

0
87
Scientists interrogated the interplay between tissue organization and morphogens by using hiPSCs downregulated for the morphogen regulator GLYPICAN-4, in which defects in tight junctions resulted in areas of disrupted epithelial integrity.
[Nature Communications]
Full Article