A Truncated and Catalytically Inactive Isoform of KDM5B Histone Demethylase Accumulates in Breast Cancer Cells and Regulates H3K4 Tri-Methylation and Gene Expression

Researchers showed that histone lysine demethylase (KDM) 5B-N-terminal truncated, accumulated in breast cancer cell lines due to remarkable protein stability relative to the canonical PLU-1 isoform, which showed a much faster turnover.