The Transcription Factor ATF3 Switches Cell Death from Apoptosis to Necroptosis in Hepatic Steatosis in Male Mice
The authors show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death.
[Journal Of Experimental Medicine] Single-cell RNA sequencing confirmed a common developmental trajectory between the thymic and blood unconventional T cells and clearly delineated this unconventional lineage in blood.
[Journal Of Experimental Medicine] Scientists showed that in pancreatic ductal adenocarcinomas (PDAC), proliferation of tumor-associated macrophagess could be driven by colony stimulating factor-1 produced by cancer-associated fibroblasts.
[Cancer Cell] Researchers examined the microenvironment in glioma and foundd that tumor-infiltrating T cells were mainly confined to the perivascular cuffs and expressed high levels of CCR5, CXCR3, and programmed cell death protein 1.