BET Inhibitors Rescue Anti-PD1 Resistance by Enhancing TCF7 Accessibility in Leukemia-Derived Terminally Exhausted CD8+ T Cells

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Ex vivo treatment of cells from acute myeloid leukemia (AML) mice and AML patients with bromodomain and extra-terminal domain (BET) inhibitors reversed CD8+ T cell exhaustion by restoring proliferative capacity and expansion of the more functional precursor-exhausted T cells.
[Leukemia]
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