IFNγ Signaling in Cytotoxic T Cells Restricts Anti-tumor Responses by Inhibiting the Maintenance and Diversity of Intra-Tumoral Stem-Like T Cells

The authors reported that specific deletion of IFNγR in CD8 T cells promoted tumor control in a mouse model of melanoma, and provide evidence of a negative feedback loop whereby IFNγ depletes stem-like T cells to restrict anti-tumor immunity.