Immunoproteasome Inhibition Prevents Progression of Castration-Resistant Prostate Cancer

The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[British Journal of Cancer]
AbstractGraphical Abstract

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News