Estrogens Drive the Endoplasmic Reticulum-Associated Degradation and Promote Proto-Oncogene c-Myc Expression in Prostate Cancer Cells by Androgen Receptor/Estrogen Receptor Signaling

Scientists investigated the regulatory effects of estrogens on endoplasmic reticulum (ER)-associated degradation (ERAD) and unfolded protein response (UPR) and their impacts on prostate carcinogenesis.