Viscosalactone B, a Natural LSD1 Inhibitor, Inhibits Proliferation In Vitro and In Vivo against Prostate Cancer Cells

Viscosalactone B was first identified as a novel lysine-specific demethylase 1 (LSD1) inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells.