Neuronal and Astrocytic CB1R Signaling Differentially Modulates Goal-Directed Behavior and Working Memory by Distinct Temporal Mechanisms

The authors demonstrated that light stimulation of opto-cannabinoid receptor 1 (CB1R) triggered canonical CB1R signaling by inhibiting cAMP, but not cGMP or IP1, signaling and activating the MAPK pathway in vitro or in vivo.