Intrathymic Dendritic Cell-Biased Precursors Promote Human T Cell Lineage Specification through IRF8-Driven Transmembrane TNF

In vitro recapitulation of TNF receptor 2 (TNFR2) signaling, by providing low-density membrane-bound precursor form of the cytokine TNF or a selective TNFR2 agonist, enhanced the generation of human T cell precursors.