CD200+ Cytotoxic T Lymphocytes in the Tumor Microenvironment Are Crucial for Efficacious Anti–PD-1/PD-L1 Therapy

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Scientists found an increase in tumor-infiltrating CD200+ cytotoxic T lymphocytes upon PD-1/PD-L1 blockade, with higher proportions of CD200+ T cells positively related to a favorable clinical outcome to anti–PD-1/PD-L1 therapy in three independent cohorts of patients with cancer.
[Science Translational Medicine]
Abstract