Phenotypic CD8 T Cell Profiling in Chronic Hepatitis B to Predict HBV-Specific CD8 T Cell Susceptibility to Functional Restoration In Vitro

Hepatitis B virus (HBV) dextramer+CD8 T cells were analyzed ex vivo for coexpression of checkpoint/differentiation markers, transcription factors, and cytokines in 35 patients with HLA-A2+chronic hepatitis B (CHB), and in 29 control HBsAg negative CHB patients who seroconverted after NUC treatment or spontaneously.