The NFIA-ETO2 Fusion Blocks Erythroid Maturation and Induces Pure Erythroid Leukemia in Cooperation with Mutant TP53

To address the role for the pathogenesis of the disease, investigators expressed the NFIA-ETO2 fusion in murine erythroblasts. They observed that NFIA-ETO2 significantly increased proliferation and impaired erythroid differentiation of murine erythroleuemia cells and of primary fetal liver-derived erythroblasts.