Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD
The authors studied mice harboring a germline hypomorphic mutation of one Runx1 allele with a loss-of-function mutation in the other Runx1 allele, which displayed many hematologic characteristics found in human RUNX1-FPD patients.
[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.
[Science Immunology] Scientists identified OTULIN deficiency as a cellular condition that licenses RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.
[Cellular & Molecular Immunology] Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome.