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e.g. organoids

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

The authors studied mice harboring a germline hypomorphic mutation of one Runx1 allele with a loss-of-function mutation in the other Runx1 allele, which displayed many hematologic characteristics found in human RUNX1-FPD patients.
[Hemasphere]
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