PD-L1 Regulates Epithelial–Mesenchymal Transition and Cancer Stem Cell Phenotypes in Hepatocellular Carcinoma through SGK2/β-Catenin Signaling Pathway

The authors reported that PD-L1 regulates not only the epithelial–mesenchymal transition but also the stem-like transition in liver cancer cells. They observed high PD-L1 expression in CD133+ liver CSCs and CSC-enriched tumorspheres.