Classical Monocyte-Derived Macrophages as Therapeutic Targets of Umbilical Cord Mesenchymal Stem Cells: Comparison of Intratracheal and Intravenous Administration in a Mouse Model of Pulmonary Fibrosis
The authors determined the changes in various immune cells, especially macrophages and monocytes, involved in the effects of MSC treatment on pulmonary fibrosis.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.