CD19 CAR Antigen Engagement Mechanisms and Affinity Tuning
Scientists used cryo-electron microscopy to determine the protein structure of several CAR binders complexed with the extracellular portion of human CD19, a target antigen found on B-cell malignancies.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.