UHRF1/UBE2L6/UBR4-Mediated Ubiquitination Regulates EZH2 Abundance and Thereby Melanocytic Differentiation Phenotypes in Melanoma

Investigators identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq data from high-pigmented and low-pigmented melanoma cells, suggesting EZH2 as a master regulator of these states.